Exosomal-derived mRNA has also been proposed to provide a more detailed definition of the genomic features of aggressive cancers such as GBM [25] by mediating O6-methylguanine-DNA methyltransferase (MGMT) and alkylpurine-DNA-N-glycosylase (APNG) which repair DNA damage leading to TMZ resistance [88]. This evidence concerns the gene MGMT and cancer.