In total, 28 Caucasian patients (16 males vs. 12 females; 57.1% vs. 42.9%) affected by CF and diagnosed with CFRD undergoing insulin therapy followed at our regional CF centre were included, with a median age of 33 years (SD 13.26, minimum age 12 years, maximum age 56 years) at the start of ETI therapy. This evidence concerns the gene INS and cystic fibrosis.