ESR1 and ovarian cancer: To illustrate the disorder status of some of such spliceosomal intrinsically disordered RBPs, Figure 6 represents AlphaFold-generated 3D structural model for one of the moonlighting RBPs involved in the regulation of alternative splicing in nervous system, RNA binding protein fox-1 homolog 2 (RBFOX2; UniProt ID: O43251), which besides regulating the alternative splicing events by binding to 5′-UGCAUGU-3′ elements can also act as a negative regulator of the human estrogen receptor (ER) signaling and play a role in some ovarian cancers [154].