EDN1 and pulmonary arterial hypertension: The administration of CGRP can stimulate pulmonary vasodilation in hypoxic-induced PH animal models and attenuate pathological vascular remodeling in PAH rat models in part by suppression of ET-1 release and attenuating the cGMP-AMP synthase (cGAS)-simulator of inferior genes (STING)-nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB) pathway, respectively [197,198,199,200].