The oncogenesis of HCC is promoted by the elevated levels of m1A58-modified tRNAs by the TRMT6/TRMT61A complex, which increases peroxisome proliferator-activated receptor delta (PPARδ) translation and stimulates cholesterol synthesis, resulting in the activation of the Hedgehog pathway and thus initiated self-renewal of HCC stem cells [43]. The gene discussed is TRMT6; the disease is hepatocellular carcinoma.