Yuan et al. detected the accumulation of Dsg-3 and Dsg-1 specific B-cells in pemphigus cutaneous lesions and postulated that the skin acts as a tertiary lymphoid organ, with infiltrating auto-reactive B-cells releasing anti-Dsg autoantibodies due to an intense cross-talk between B cells and IL-21- and IL-17A-producing CD4+ T cells. The gene discussed is DSG1; the disease is pemphigus.