Based on the available literature, eosinophils, IgG autoantibodies, IgE autoantibodies, SP and its receptor NK1R, IL-31 and its receptor OSMRb, IL-31RA, IL-13, IL-4, periostin, and basophils may be responsible for pruritus in BP and could be potential therapeutic targets [27]. The gene discussed is POSTN; the disease is Pruritus.