Acacetin also inhibits the expression of NLRP3 in cerebral ischemia-reperfusion injury [111], suppresses NLRP3 expression and enhances gp78-mediated NLRP3 ubiquitination in depression-associated dry eye disease [112], and reduces the expression of NLRP3 in mice with Alzheimer’s disease [113]. This evidence concerns the gene NLRP3 and early-onset autosomal dominant Alzheimer disease.