HMOX1 and cardiac hypertrophy: Other studies have shown that acacetin (10 mg/kg, 7 days; 10 mg/kg, 16 weeks) also can upregulate the expression of anti-oxidants, including superoxide dismutases (SODs), heme oxygenase 1 (HO-1) in acute lung injury, cardiac hypertrophy, diabetes-induced cardiomyopathy, and myocardial ischemia/reperfusion injury animal models [80,81,82,83,84].