MAPT and Alzheimer disease: GSPE:Disrupts and disintegrates the ultrastructure of native PHFs in AD brain.Inhibits tau aggregation and promotes dissociation from already assembled filaments.Significantly inhibits tau-mediated neuropathology in the TMHT mouse model.Suggested as a potential therapeutic agent for tau-mediated neurodegenerative conditions, like AD. Resveratrol:Ineffective in altering the ultrastructure of PHFs as compared to GSPE.Not effective in inducing width expansion of filaments.