Curcumin:Reduces oxidative damage and amyloid pathology in AD models.Shows anti-inflammatory properties, inhibits pro-inflammatory transcription factors, and may disaggregate Aβ plaques, reducing neuroinflammation and protecting against AD progression. NanoCurcTM:Protects neuronally differentiated human SK-N-SH cells from ROS (H2O2) mediates insults and rescues cells previously insulted with H2O2.In vivo, decreases levels of H2O2, caspase 3, and caspase 7 activities in the brain, and increases glutathione concentrations. The gene discussed is CASP3; the disease is Alzheimer disease.