Cocoa polyphenolic extract: Exerts neuroprotective effects by activating the BDNF survival pathway. This activation counteracted neurite dystrophy induced by Aβ plaques and oligomers, suggesting the potential of cocoa polyphenols as preventive agents against neurodegenerative diseases, such as AD by reducing oxidative stress and promoting neuronal survival. This evidence concerns the gene BDNF and Alzheimer disease.