Polyphenol-enriched extracts from Arabidopsis thaliana mutants:Exhibits anti-inflammatory effects, especially the xpf3 mutant.Attenuates TNF-α secretion in mixed glial cultures, with a notable reduction observed in APOE4 cultures compared to APOE3 and APOE2.Could serve as a potential therapeutic agent for AP-OE-modulated neuroinflammation, a characteristic of AD. This evidence concerns the gene APOE and Alzheimer disease.