GSPE:Interferes with the assembly of tau peptides into neurotoxic aggregatesReduces the development of AD-type tau neuropathology.Decreases tau phosphorylation at specific sites, thereby preventing the formation of NFTs and reducing ERK 1/2 activity.Led to a significant reduction in the accumulation of insoluble tau and hyperphosphorylation of tau in the brains of TMHT mice. This evidence concerns the gene MAPT and Alzheimer disease.