GPX4 and Alzheimer disease: TA:Acts as a dual-acting therapeutic agent against AD and ferroptosis.Modulates Aβ42 and TAU aggregation.Chelates metal ions, reducing oxidative stress.Rescues mitochondrial function.Activates and enhances GPX4 levels, inhibiting ferroptosis.Activates Nrf2, regulating ferroptosis in neuronal cells.Inhibits lipid peroxidation and protein oxidation, providing neuroprotective effects. EGCG:Inhibits Aβ42 aggregation.Shows antioxidant properties, reducing oxidative stress.Does not directly activate GPX4 but inhibits RSL3-induced GPX4 inhibition.