TLB:Improves cognitive deficits in both animal models.Ameliorates neuroinflammation and oxidative stress by inhibiting the HMGB1/TLR4/NF-κB signaling pathway and activating the SIRT3/SOD2 pathway, which helps to restore redox homeostasis and suppress neuroinflammation. This evidence concerns the gene HMGB1 and cognition.