PPARA and Hepatic steatosis: Luo et al. reported that FA reduced hepatic steatosis and activated liver PPARα targets (CPT1A, ACOX1, and HMGCS2) in mice fed a high-fat diet, indicating that FA effectively prevents HFD-induced NAFLD by activating PPARα, increasing hepatic energy expenditure, and reducing intrahepatic TG accumulation [37].