MAPK8 and Insulin resistance: SalB effectively inhibits the activation of JNK and NF-κB in pancreatic tissues, decreases the expression of pro-apoptotic proteins Bax and Bim, increases the levels of the anti-apoptotic protein Bcl-2, and significantly reduces the activities of caspase-9 and caspase-3, which in turn reduces cell apoptosis, improves insulin resistance, and thus lowers blood glucose levels in rats [44,45,80].