Since curcumin was reported to inhibit NF-κB activation in prostate cancer cells by sensitizing them to TNF-related apoptosis-inducing ligand (TRAIL), the response of PC3 cells to combinational treatments of curcumin as a sensitizer for TRAIL-induced cell death was examined, demonstrating the utility of the microfluidic system. This evidence concerns the gene TNFSF10 and Familial prostate cancer.