EPCAM and posterior cortical atrophy: As a proof of concept to isolate CTCs in vivo from blood of PCa patients, a medical wire (CellCollector) was used to isolate CTCs in blood samples of PCa patients; the gold-coated tip of the wire was covered by a polycarboxylate layer and, following activation, the wire tip was functionalized with the EpCAM antibodies to capture target CTCs for enumeration and molecular characterization [243].