CPB2 and cardiovascular disorder: In cardiovascular disease studies, TAFI, which was discovered by Hendriks et al. in serum in 1989 and previously defined as carboxypeptidase U (CPU), deserves equal attention among researchers typically focusing on blood clotting or the fibrinolytic system due to its important role in maintaining blood circulation and the delicate balance between coagulation and fibrinolysis [10,11,12,13].