On the contrary, a low Bax/Bcl-2 ratio indicated resistant cells, as recorded in renal and testis tissues of CIS + QUE rats (p < 0.01 and p < 0.05, respectively) and CIS + QUE.NPs rats (p < 0.001 and p < 0.01, respectively) compared to the CIS group. The gene discussed is BCL2; the disease is in situ carcinoma.