IGHE and Increased total eosinophil count: We first examined the effect of the CBD-X extract on primary human Th2 cells, as their cytokines play a central role in asthma and drive key features of the disease, including eosinophilia, mucus hypersecretion, bronchial hyper-responsiveness (BHR), IgE production, and increased susceptibility to exacerbations [11].