AGT and myocardial ischemia: On the other hand, no significant increase in infarct sizes was noticed in hypertrophied hearts of Dahl salt-sensitive hypertensive rats [66] or SHR [67], while other studies have shown that diabetic animals [68], those with angiotensin II-dependent hypertension [69], or those with two-kidney one-clip Goldblatt hypertension [70] exhibit even smaller cardiac infarct sizes in response to acute myocardial ischemia/reperfusion in comparison to respective normotensive controls.