ATR and acute promyelocytic leukemia: Studies have shown that ATR has a significant anti-proliferative effect on human ovarian cancer (A2780), human colon cancer (HT-29, LS-174), breast cancer (MCF-7, SK-BR-3, T47D, MDA-MB-231, 4T1), human cervical adenocarcinoma (HeLa), human promyelocytic leukemia, human hepatocellular carcinoma (SK-Hep1, Huh-7, SNU-182), human T cell lymphocytic leukemia, Jurkat, and human melanoma cell (FemX) lines [8,17,18,32,33,34].