Furthermore, in vitro and in vivo studies [17] have shown that this isoflavone exerts potent antioxidant effects, neutralizing reactive oxygen species (ROS) and reducing oxidative stress at the injury site [35], which may take place through the positive modulation of the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway, as proposed by other authors in mice models such as LPS-induced lung injury [32], ovalbumin-induced asthma [36], and TNBS-induced colitis [33]. Here, NFE2L2 is linked to colitis.