BCL2 and myocardial infarction: These studies have shown that inhibition of apoptosis through increasing the BCL2/BAX ratio contributes to the survival of cardiomyocytes in the peri-infarct area after myocardial infarction and reperfusion (MI/RI), reducing the degree of cardiac damage and preventing the opening of the mitochondrial permeability pore due to hypoxia [46].