This reduces cardiomyocyte apoptosis and protects against myocardial ischemia by upregulating BCL2 expression while downregulating BAX and CASP3 [50] or, for example, trimetazidine (TMZ), which was found to reduce the BAX/BCL2 ratio and CASP3 expression and inhibit cardiomyocyte apoptosis induced by reperfusion injury (I/R) by activating the Akt signaling pathway [51]. This evidence concerns the gene CASP3 and myocardial ischemia.