ACHE and Parkinson disease: This research aims to determine whether 6-shogaol prevents the development of PD in rodents induced by rotenone in Wistar rats based on the behavioral paradigms (open field test, forced swim test, rotarod test, and catalepsy test), biochemical parameters (Oxidative stress markers, pro-inflammatory cytokines, neurotransmitter levels, and AChE), histopathological examination and molecular docking.