Furthermore, CXCL12 (C-X-C motif chemokine ligand 12) was the most central node in the network, and it was found that through an activation of the CXCR3 receptor, this chemokine promotes caspase activation, leading to apoptosis, and IOP elevation in a rat model of ocular hypertension [88]. The gene discussed is CXCL12; the disease is ocular hypertension.