ITGB3 and open-angle glaucoma: Moreover, ITGB3, which encodes integrin beta-3 (β3), showed an elevated betweenness centrality value in our network, and its role in POAG has not yet been investigated; however, integrin signaling pathways may have a role in the pathogenesis of glaucoma and in the increase in TM resistance to the AH outflow [70].