The genes largely described to be involved in glaucoma, which were identified in the XFG vs. CTRL network, include the following: HIF1A (node linked to the enriched “mTOR signaling pathway”); SOD2, which is a target of the central node hsa-let-7a-5p; and TGFBR2, belonging to the “TGF-beta signaling pathway” [61]. The gene discussed is HIF1A; the disease is glaucoma.