Additionally, DLG4 (discs large MAGUK scaffold protein 4) and several proinflammatory chemokines and cytokines already known to have a role in glaucoma, e.g., C-X-C motif chemokine ligand 8 (CXCL8), tumor necrosis factor (TNF), and interleukin-6 (IL-6), were other central nodes in the network. The gene discussed is CXCL8; the disease is glaucoma.