Furthermore, we identified the gene encoding HIF-1α as a crucial gene in our network analyses, and several experimental reports, along with one on the etiopathogenic hypothesis of the onset and progression of glaucoma (i.e., perfusion deficits at the optic nerve head), corroborated the detrimental role of this transcription factor in glaucoma pathogenesis [36,37,38]. Here, HIF1A is linked to glaucoma.