Liton et al. 2006 [31], comparing the gene expression profiles of CTRL and POAG TM tissues (isolated postmortem tissues from patients), found that the top deregulated genes were coding proteins involved in inflammation such as: chemokine (C-X-C motif) ligand 6, chemokine (C-C motif) ligand 5, immune-associated nucleotides, the interleukin 1 receptor type II, transthyretin, haptoglobin, and myelin basic proteins. Here, IL1R2 is linked to open-angle glaucoma.