The network centrality analysis evidenced the following five central nodes as the new predicted genes involved in glaucoma, that can be potentially further validated for glaucoma treatment, given that no entries were retrieved about these genes on PubMed and clinicaltrials.gov: HTR5A (5-HT5A), FSTL5 (follistatin-like 5), EXOSC3, (exosome component 3), FBXL2 (the f-box and leucine-rich repeat protein 2), and CLIC2 (the chloride intracellular channel 2). The gene discussed is CLIC2; the disease is glaucoma.