In our previous study, it was confirmed that SPV can significantly induce autophagy and apoptosis in glioma cells to anti-tumor, but it has only been preliminarily confirmed that SPV can induce the phosphorylation of AKT target to anti-tumor, and how SPV further affects cell apoptosis, autophagy, and invasion through AKT is still unknown. This evidence concerns the gene AKT1 and glioma.