The combination of birinapant and irradiation or irradiation alone also significantly inhibited tumor growth in UM-SCC-11B xenografts overexpressing FADD and BIRC2, but not in UM-SCC-1 xenografts showing weaker growth and FADD/BIRC2 copy expression and heterozygous CASP8 mutation [71]. This evidence concerns the gene CASP8 and neoplasm.