Of 39 genes, 21 (BCL2L1, CA12, CTSD, HIF1A, HPSE, HSP90AA1, IGF2R, JAK1, MAPK1, MMP13, MMP3, MSR1, PTAFR, PTGS1, PTPN1, SQLE, SYK, TYMP, TYMS, VDR, and VEGFA) were showed the involvement in the metastasis, whereas the other genes could be the co-regulators of the cancer metastasis as demonstrated through enrichment analysis. The gene discussed is HPSE; the disease is cancer.