Based on data integration, 39 proteins (APH1A, BCL2L1, CA12, CTSD, FAAH, FDPS, HIF1A, HMGCR, HPRT1, HSD17B10, HSP90AA1, JAK3, KMT5A, MAPK1, MMP3, MSR1, PNP, PTGS1, PTPN1, SQLE, SYK, TDP1, TYMP, TYMS, VDR, VEGFA, CDC25C, KIF20B, MMP13, PDE4D, ALOX5AP, CDK5R1, MGAM, PTAFR, BLM, HPSE, IGF2R, INSR, and JAK1) were identified and assessed for their role in cancer metastasis. The gene discussed is PDE4D; the disease is cancer.