In multivariate analysis, higher clinical stage (HR 3.38, CI95% 0.17–9.77, p = 0.025) and low claudin-1 expression (HR 7.91, CI95% 1.79–35, p = 0.006) retained significance as independent prognostic factors of shorter survival in papillary thyroid cancer (Table 4). Here, CLDN1 is linked to thyroid gland papillary carcinoma.