-Oxaliplatin-induced claudin-1 expression is associated with p38/GSK3β/Wnt-β-catenin pathway-Oxaliplatin resistance is mediated by claudin-1-induced apoptosis resistance-6F6-ADC suppresses CRC growth in vivo-Sequential oxaliplatin +6F6-ADC exhibits a stronger anti-cancer effect and increased survival than oxaliplatin monotherapy. This evidence concerns the gene MAPK1 and colorectal carcinoma.