CLDN4 and cancer: -D@C-LPs bind specifically with claudin-4 expressing cancer cells-Claudin-4 in case of PDAC is exposed superficially, whereas access to claudin-4 in case of normal pancreatic tissue is hindered-D@C-LP resulted in significant suppression of tumor growth in vivo and prolonged mice survival compared to free doxorubicin-D@C-LP was associated with no major systemic toxicities