While claudin-4 expression varies between MTC specimens, datelliptium, an inhibitor of Rearranged during Transfection (RET) proto-oncogene, downregulated mesenchymal markers and claudin-1 in MTC cells and suppressed EMT, exhibiting a significant anti-cancer effect in vivo (xenograft model) through RET inhibition [41]. The gene discussed is CLDN1; the disease is medullary thyroid gland carcinoma.