Overall, the functions of these genes in tumors, most of which have been well established in gliomas, suggest that KIF14, ASPM, CCR5, GINS4, POLD3, TLR2, KIF2C, KPNA2, ITGB2, PLOD1, and CTSZ can be considered key prognostic factors for the overall survival of glioma patients. This evidence concerns the gene ITGB2 and central nervous system cancer.