Overall, the functions of these genes in tumors, most of which have been well established in gliomas, suggest that KIF14, ASPM, CCR5, GINS4, POLD3, TLR2, KIF2C, KPNA2, ITGB2, PLOD1, and CTSZ can be considered key prognostic factors for the overall survival of glioma patients. Here, POLD3 is linked to central nervous system cancer.