Recently, we found that the P2RX2, P2RX7, P2RY2, A3, NTE5, and ADA gene expression is altered in an intestinal low-grade inflammation associated with obesity-induced T2D mouse model, suggesting that these purinergic signaling components might be relevant in the pathophysiology of T2D and could represent potential therapeutic targets in gastrointestinal tract dysfunctional complications related to this disease [114]. This evidence concerns the gene P2RY2 and type 2 diabetes mellitus.