Interestingly, a similar study using a DSF assay was used to investigate the stabilization effect of ebselen derivatives on SOD1(A4V), aiming for improved SOD1 dimer stabilization and drug-like properties; the selected compound demonstrated a significant delay in ALS disease onset in SOD1(G93A) mice and remarkable neuroprotective activities [20,118]. Here, SOD1 is linked to amyotrophic lateral sclerosis.