TNF and arthritic joint disease: This PPI network was imported into Cytoscape 3.10.0 using the Cytohubba plug-in, and the top 10 core targets, TNF, AKT1, IL6, IL1B, VEGFA, TP53, CASP3, PTGS2, JUN, and EGF, were identified as the hub genes/markers that may play a key role for arthritis treatment (Figure 3B).