Compounds such as quercetin, naringenin, astilbin, and taxifolin have demonstrated their ability to inhibit the production of pro-inflammatory cytokines, such as TNF-α, IL-1β, and IL6, which are the key players in OA and RA pathogenesis causing inflammation, cartilage degradation, and bone erosion [10,19,20]. The gene discussed is IL6; the disease is rheumatoid arthritis.