FOXO3 and neoplasm: Furthermore, the expression levels of GADD45A, p-JNK, and p-P38 were significantly increased, while the levels of CDK1, Cyclin B, PLK1, CDC25C, p-FOXO3a, and p-AKT were significantly decreased in the tumor tissue of the NF113-treated group compared to the vehicle-treated group, consistent with the in vitro data (Figure 6G,H).