Interestingly, GSEA and Gene Ontology Enrichment Analysis demonstrated that while PRKACA-high tumors exhibited differential enrichment of genes that regulate cell motility, migration, and metastasis in the GC and CRC cohorts, there was enrichment of genes that regulate cell proliferation and growth in the GC, but not the CRC, PRKACA-low subset. This evidence concerns the gene PRKACA and colorectal carcinoma.