In the CRC cohort, high PRKACA expression was associated with younger age groups (particularly the 60-years-and-below age group), left-sided colon cancer, rectal cancer, and nodal stage, but not with gender, race/ethnicity, pathological tumor stage, metastasis, TNM stage, lymphovascular and vascular invasion, and histological type (Table 1). The gene discussed is PRKACA; the disease is rectal cancer.