PRKACA and cancer: For example, whilst PKA signaling has been demonstrated to regulate actomyosin contractility and cell migration, as well as membrane deformation, actin polymerization, cancer cell invasion, and metastasis, through phosphorylation of CIP4 and FAK [23,24,25,26], activating PRKACA mutations have been associated with smaller tumor sizes of adrenocortical adenomas [27,28,29,30].