PRKACA and colorectal carcinoma: Moreover, high PRKACA expression was associated with the chromosomal instability and microsatellite stable (MSS) subtypes of CRC and with tumors having low mutation count, low MSI Sensor score, and high Fraction Genome Altered and Aneuploidy scores, but not with MSI MANTIS score and tumor mutational burden (TMB) (Table 2).