A comparison of the core enrichment gene sets in the GC and CRC PRKACA-high subsets showed that only two enriched genes, EGFR and LAMP2, overlapped between the GC and CRC subsets, whereas the GO enrichment analysis found that the enriched biological processes, molecular functions, and cellular components subserved by the enriched genes were similar between the GI cancers. This evidence concerns the gene PRKACA and colorectal carcinoma.