In fact, it has been observed that a repeated weekly treatment with a 5 mg/kg dose of cisplatin induces cognitive deficits, hippocampal activation of NF-κB and expression of downstream inflammatory mediators in rats [56], and a decreased percentage of alternations in the Y maze, indicative of a poorer hippocampal spatial memory, accompanied by pro-inflammatory and proapoptotic hippocampal markers [29]. Here, NFKB1 is linked to Cognitive impairment.