Advanced glycation end products (AGE) that originate from the metabolic dysregulation observed in DM are able to generate reactive oxygen species (ROS) and when interacting with their receptor (RAGE) can trigger other pathways such as MAPK (ERK1/2, p38, JNK), PI3K/Akt, JAK/STAT1 that lead to vascular diabetic complications [86,87]. This evidence concerns the gene MAPK8 and diabetes mellitus.