Highly ranked core target proteins, including EGFR, STAT3, CASP3, PTGS2, ERBB2, ICAM1, GRB2, PIK3CA, CASP8, FYN, and SYK, are involved in inflammation and microglial activation, which are crucial for the treatment of AD with OUA. The gene discussed is CASP8; the disease is Alzheimer disease.