TP53 and cancer: Subsequent enrichment analysis of KEGG pathways unveiled their intricate association with various critical signaling cascades, notably encompassing cancer-related pathways, the AGE-RAGE signaling pathway implicated in diabetic complications, the pivotal PI3K-Akt signaling cascade, the regulatory p53 signaling pathway, and the intricate NF-κB signaling pathway, among others (as depicted in Figure 4B).