Among the IBD-related genes targeted by ZP were AKT1, ALB, CASP3, CCL2, CLDN4, CRP, CSF2, CTNNB1, CXCL10, CXCL2, CXCL8, FOXP3, GPBAR1, HMOX1, HPR, ICAM1, IFNG, IL10, IL17A, IL18, IL1B, IL2, IL6, JAK1, JAK2, MPO, NFKBIA, NR1H4, OCLN, PPARG, PTGS2, RIPK2, STAT1, STAT3, TLR4, TNF, and TYK2. The gene discussed is PTGS2; the disease is inflammatory bowel disease.