INS and obesity due to melanocortin 4 receptor deficiency: miRNA-148a is reported to cause hypomethylation and increases the expression of genes that play a significant role in growth and development (insulin (INS), insulin-like growth factor-1 (IGF1), fat mass- and obesity-associated gene (FTO), forkhead box protein 3 (FOXP3), nuclear factor erythroid 2-related factor 2 (NRF2), and lactase gene (LCT)) by suppressing DNMT1 transcription [161].