SCD and obesity due to melanocortin 4 receptor deficiency: Considering that SCD-1 is regulated by factors such as saturated fat intake, carbohydrate consumption [31], and metabolic conditions, its elevated activity is associated with metabolic diseases such as insulin resistance, obesity, type 2 diabetes, and cardiovascular dysfunction, since the excessive production of MUFAs can lead to the accumulation of fat in the liver and adipose tissue, favoring the development of cardiometabolic complications, which have been associated with obesity, IR, DM2, and MetS [32,33].