Therefore, we suggest that adverse intrauterine environments, such as hyperglycemia and maternal obesity during pregnancy, can affect the DNA methylation pattern of promoters of LPL, involved in glucose and lipid metabolism, as well as MC4R, involved in obesity and weight gain, both in mothers and their children, thereby providing a potential mechanism for long-lasting effects. Here, LPL is linked to obesity due to melanocortin 4 receptor deficiency.