The objective of our research was to evaluate the impact of a 6-week aerobic-resistance exercise per se and an aerobic-resistance exercise combined with an ad libitum high-protein, low-glycemic index diet on the concentrations of irisin (IR) and omentin (OMEN), as well as on cholesterol levels in men with abdominal obesity, compared with men with abdominal obesity who did not participate in any intervention (control group). This evidence concerns the gene FNDC5 and Abdominal obesity.