IGF1 and polycystic ovary syndrome: Conversely, short-term studies found that an 8 h TRE intervention (8 a.m.–4 p.m.)over five weeks in anovulatory women with PCOS also significantly increased IGF1 levels, along with reductions in body weight, fat mass, visceral fat area, waist-to-hip ratio, insulin, HOMA-IR, and hsCRP [13].