p53, a crucial tumor suppressor, was initially discovered as a binding partner of the SV40 large T-antigen [14], while some recent studies also identified it as a host cell response protein, which regulates cellular signaling pathways involved in innate immune control, cell cycle, DNA repair, apoptosis, etc., to cope with a wide range of stress factors including viral infection [15,16]. The gene discussed is TP53; the disease is viral infectious disease.