TNFRSF1B and immune system disorder: Although the shared genetics between URIs and Meniere’s disease have not been well studied, URI-associated non-synonymous variants in the genes NFKB1, IL7R, and TNFRSF13B—classified as Mendelian immune disorder genes—suggest shared heritability with autoimmune conditions and immune deficiency, particularly through the TNFR2 pathway [12].