This damage can disrupt the production of vasodilators (nitric oxide and prostacyclin) and increase proinflammatory cytokines (such as tumor necrosis factor-α, interleukin-6, and interleukin-1) due to changes in blood clotting and fibrinolysis, heightening the risk of thrombotic complications that might impair inner ear function and contribute to Meniere’s disease symptoms [9], especially sensorineural hearing loss [24]. Here, TNF is linked to hearing loss disorder.