Also in this setting, the 2023 ESC consensus proposes a diagnostic algorithm incorporating age-specific NT-proBNP reference values—NT-proBNP ≥ 125 pg/mL for those younger than 50 years of age, NT-proBNP ≥ 250 pg/mL for ages 50 to 75 years, and NT-proBNP ≥ 500 pg/mL for those older than 75 years—indicating probable HF diagnosis necessitating echocardiography within 6 weeks (Table 3). The gene discussed is NPPB; the disease is hydrops fetalis.