NPPB and heart failure: Nevertheless, a clinical consensus statement from the ESC Heart Failure Association in 2023 proposed age-specific NT-proBNP cutoffs for diagnosing HF: NT-proBNP ≥ 450 pg/mL for patients under 50 years; NT-proBNP ≥ 900 pg/mL for those aged 50 to 75 years; and NT-proBNP ≥ 1800 pg/mL for patients over 75 years [12].