The graph presents the proportion of participants that were heterozygous for the p.Val50Met variants (labeled as 1) versus TTR+ participants without the p.Val50Met variant (labeled as 0), according to the main principal component of the study, namely, the polyneuropathy (PN), cardiomyopathy (CM), gastrointestinal (GI), and general symptoms (GS) components. The gene discussed is TTR; the disease is poikiloderma with neutropenia.