The sequencing of chromosome 21 provided several insights into DS pathology such as overexpression of interferon receptors (IFNAR1, IFNAR2, INFAG2, and Il-10B), increased production of amyloid peptides (APP and BACE2), and hyper-phosphorylation of Tau (DYRK1A and RCAN1) [81]. Here, MAPT is linked to Dravet syndrome.