Prolonged use of glucocorticoids at supraphysiologic doses prescribed as anti-inflammatory and immunosuppressive agents can suppress the function of several hypothalamic–pituitary axes, resulting in a decrease in the production of pituitary hormones such as ACTH, TSH, and Gn, which may become clinically evident during steroid treatment (CeH and/or CeHg) or after withdrawal (secondary adrenal insufficiency) [93]. Here, POMC is linked to Adrenal insufficiency.