Given the variability in any population’s genetics, particularly in some Latin American Mestizo populations, which harbor varying degrees of Caucasian contribution, and interactions with environmental factors, which may exert epigenetic influences on clinical manifestations and even the type of ILD, this study aimed to investigate whether the MUC5B rs35705950 promoter variant is associated with the development of patterns predominantly fibrotic, such as UIP, in a population of Mexican patients with ASSD-ILD [21]. The gene discussed is MUC5B; the disease is idiopathic pulmonary fibrosis.