They find that both the syndromic and sporadic cases of CM1 often contain variants in chromatin-remodeling genes, which they further separate into five categories (W1–W5), including SETD2, NSD3, SMID3 (W1 category), KDM5 (W2 category), EP300, CREBBP (W3 category), SETBP2 (W4 category), and HIST1 (W5 category) [28]. The gene discussed is NSD3; the disease is Chiari malformation type I.