NFKB1 and type 2 diabetes mellitus: More importantly, NF-κB was highly upregulated in the current study and is considered one of the major regulators of inflammatory processes implicated in the pathogenesis of diabetic complications; hence, the persistent activation of NF-κB in T2DM may contribute to the inflammatory milieu that characterizes both microvascular and macrovascular complications, reinforcing the need for therapeutic strategies targeting this pathway [36].