While the initial findings were that CHIP and MPNs promote atherogenesis and, conversely, the inflammatory state that accompanies atherosclerosis feeds back to the bone marrow to selectively promote mutant hematopoietic stem cell proliferation, more recent studies have found that other forms of cardiovascular disease, particularly heart failure, promote the same adverse feedback loop, as described below [6]. The gene discussed is STUB1; the disease is atherosclerosis.